SCHEMBL887359

SCHEMBL887359

OP1(=S)NC(c2ccccc2)C(c2ccccc2)N1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GBA1 P04062 1/20 0.44
CHRNA7 P36544 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
SLC18A3 Q16572 1/20 0.35
SIGMAR1 Q99720 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
LMNA P02545 2/20 0.34
MAPK1 P28482 2/20 0.34
GAA P10253 1/20 0.34
P2RX7 Q99572 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 2/20 0.33
KDM4E B2RXH2 1/20 0.33
PKM P14618 1/20 0.33
ALOX12 P18054 1/20 0.33
RAB9A P51151 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP1A2 P05177 2/20 0.32
CYP3A4 P08684 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL887305 0.77 GBA1 (0.44) GBA1CHRNA7SMN1; SMN2SLC18A3SIGMAR1
SCHEMBL14523113 0.70 GBA1 (0.35) GBA1CHRNA7SMN1; SMN2ALDH1A1HPGD
SCHEMBL887283 0.67 GBA1 (0.39) GBA1CHRNA7SMN1; SMN2SLC18A3SIGMAR1
SCHEMBL10376420 0.66 SMN1; SMN2 (0.61) GBA1CHRNA7SMN1; SMN2SLC18A3SIGMAR1
SCHEMBL10537566 0.66 SMN1; SMN2 (0.61) GBA1CHRNA7SMN1; SMN2SLC18A3SIGMAR1
SCHEMBL2682379 0.66 SMN1; SMN2 (0.61) GBA1CHRNA7SMN1; SMN2SLC18A3SIGMAR1
SCHEMBL31146730 0.66 SMN1; SMN2 (0.61) GBA1CHRNA7SMN1; SMN2SLC18A3SIGMAR1
SCHEMBL30943497 0.66 SMN1; SMN2 (0.61) GBA1CHRNA7SMN1; SMN2SLC18A3SIGMAR1
SCHEMBL887368 0.65 EPHX1 (0.36) MEN1KMT2ATSHRCYP2C19HTR2B
Methane SCHEMBL11777489 0.64 SMN1; SMN2 (0.58) GBA1CHRNA7SMN1; SMN2SLC18A3SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902207-B2 Process for production of amines TAKASAGO INTERNATIONAL CORPORATION (JP) 2011-03-08 US disclosed
US-7902207-B2 Process for production of amines TAKASAGO INTERNATIONAL CORPORATION (JP) 2011-03-08 US disclosed
US-20070142639-A1 Process for production of amines TAKASAGO INTERNATIONAL CORPORATION (JP) 2007-06-21 US disclosed
US-20070142639-A1 Process for production of amines TAKASAGO INTERNATIONAL CORPORATION (JP) 2007-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142639-A1 Process for production of amines SMS, CCNT1, PEAK1 GBA1 2213/4885CHRNA7 2076/4885SMN1; SMN2 2249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.