SMS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL30249742	1.00	2/20
SCHEMBL5055541	0.76	2/20
SCHEMBL11037776	0.69	2/20
SCHEMBL11040771	0.69	2/20
SCHEMBL11040828	0.69	2/20
SCHEMBL11044260	0.69	2/20
SCHEMBL1770054	0.69	2/20
Hydrochloric Acid (SCHEMBL11043510)	0.68	2/20
SCHEMBL11042510	0.68	2/20
SCHEMBL5007882	0.67	2/20
SCHEMBL11040743	0.67	2/20
SCHEMBL6907682	0.64	2/20
SCHEMBL8388991	0.64	2/20
SCHEMBL11041134	0.64	2/20
SCHEMBL8385440	0.62	2/20
SCHEMBL11165247	0.61	2/20
SCHEMBL10563077	0.53	2/20
SCHEMBL10563851	0.52	2/20
Methylthioadenosine (SCHEMBL7124285)	0.72	1/20
SCHEMBL30760710	0.71	1/20

Clinical trials — most relevant to SMS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study	PHASE4	COMPLETED
Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arsenic	PHASE4	COMPLETED
Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients	PHASE4	RECRUITING
Efficacy of Citicoline Eye Drops 2% on Visual Field Preservation in Patients With Open Angle Glaucoma	PHASE3	RECRUITING
L-Arginine in Pre-Eclampsia	PHASE3	COMPLETED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo	PHASE2	UNKNOWN
Hereditary Sensory Neuropathy Serine Trial	PHASE2	UNKNOWN
STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH	PHASE2	COMPLETED
Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients	PHASE2	COMPLETED
Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation	PHASE1	COMPLETED
Spermine Measuring Device Evaluation Protocol	nan	WITHDRAWN
Dietary Effects of Sulfur Amino Acids	nan	COMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Genetic Variants and Regulation of Specialized Pro-resolving Mediator	nan	RECRUITING
Multi-omics Study in Citrin Deficiency	nan	ACTIVE_NOT_RECRUITING
External Nitric Oxide Measurement Through SNO Degradation	nan	ENROLLING_BY_INVITATION
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
An Exploratory Clinical Study on Autophagy and Multi-level Molecular Profiling During Spermidine Supplementation	nan	UNKNOWN
Bioavailability of Spermidine in Healthy Males	nan	ACTIVE_NOT_RECRUITING
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Treating Oxidative Stress and the Metabolic Pathology of Autism	nan	COMPLETED
Arginine Metabolism in Youth With Type 2 Diabetes	nan	RECRUITING
To Identify Potential New Urine Markers for the Screening of Prostate Cancer	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a SMS binder may also engage these)

Protein	Name	Similarity
P97355	—	1.000	P97355 →
Q3SZA5	—	1.000	Q3SZA5 →
Q29LW1	—	0.988	Q29LW1 →
Q9VIK9	—	0.987	Q9VIK9 →
ELP1	Elongator complex protein 1	0.987	landscape →
Q9W1V1	—	0.987	Q9W1V1 →
B4I8G2	—	0.987	B4I8G2 →
A0A1D6NER6	—	0.987	A0A1D6NER6 →
P34254	—	0.986	P34254 →
Q9ZS45	—	0.986	Q9ZS45 →
Q8VYX1	—	0.986	Q8VYX1 →
Q9ZTR0	—	0.986	Q9ZTR0 →
A8XFF4	—	0.985	A8XFF4 →
O48661	—	0.985	O48661 →
Q7TT37	—	0.985	Q7TT37 →
Q9CQN1	—	0.985	Q9CQN1 →
Q6NTR1	—	0.985	Q6NTR1 →
Q8VY78	—	0.985	Q8VY78 →
P00927	—	0.985	P00927 →
Q3THK7	—	0.985	Q3THK7 →
B3P4N5	—	0.985	B3P4N5 →
Q16NS8	—	0.985	Q16NS8 →
Q5YLB4	—	0.985	Q5YLB4 →
GMPS	GMP synthase [glutamine-hydrolyzing]	0.985	landscape →
B4QI55	—	0.984	B4QI55 →
Q14AI0	—	0.984	Q14AI0 →
Q7XR60	—	0.984	Q7XR60 →
Q6NTW6	—	0.984	Q6NTW6 →
Q9W3C1	—	0.984	Q9W3C1 →
Q8VHU4	—	0.984	Q8VHU4 →