SCHEMBL8874393

SCHEMBL8874393

COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CCC2(C)C

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 4/20 0.78
CHRM2 P08172 1/20 0.39
CHRM4 P08173 1/20 0.39
CHRM5 P08912 1/20 0.39
CHRM1 P11229 1/20 0.39
CHRM3 P20309 1/20 0.39
OPRM1 P35372 2/20 0.35
OPRD1 P41143 2/20 0.35
OPRK1 P41145 2/20 0.35
OPRL1 P41146 2/20 0.35
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
HPGD P15428 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
SIGMAR1 Q99720 1/20 0.35
LPAR1 Q92633 6/20 0.35
CYP3A4 P08684 2/20 0.34
FNTA P49354 1/20 0.34
FNTB P49356 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15678894 0.94 TACR1 (0.70) TACR1CHRM2CHRM4CHRM5CHRM1
SCHEMBL8652171 0.88 TACR1 (0.73) TACR1CHRM2CHRM4CHRM5CHRM1
Dapitant SCHEMBL7768046 0.88 TACR1 (1.00) TACR1CHRM2CHRM4CHRM5CHRM1
Dapitant SCHEMBL121135 0.88 TACR1 (1.00) TACR1CHRM2CHRM4CHRM5CHRM1
Dapitant SCHEMBL30695498 0.88 TACR1 (1.00) TACR1CHRM2CHRM4CHRM5CHRM1
Dapitant SCHEMBL8543936 0.88 TACR1 (1.00) TACR1CHRM2CHRM4CHRM5CHRM1
Dapitant SCHEMBL7582571 0.88 TACR1 (1.00) TACR1CHRM2CHRM4CHRM5CHRM1
Dapitant SCHEMBL13575759 0.88 TACR1 (1.00) TACR1CHRM2CHRM4CHRM5CHRM1
Dapitant SCHEMBL6908668 0.88 TACR1 (1.00) TACR1CHRM2CHRM4CHRM5CHRM1
Dapitant SCHEMBL6437147 0.88 TACR1 (1.00) TACR1CHRM2CHRM4CHRM5CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5624950-A USEFUL IN TREATMENT OF ANALGESIA, INFLAMMATION, ASTHMA, ALLERGIES, CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, IMMUNE SYSTEM DISORDERS, ANTISPASMODIC AGENTS, ANTIEMETIC AGENTS RHONE-POULENC RORER S.A. (FR) 1997-04-29 US disclosed