Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 15/20 | 0.81 |
| ▸ | HTR2A known ✓ | P28223 | 12/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8875714 | 1.00 | HTR2C (0.81) | HTR2CHTR2ALMNAPMP22NPSR1 | |
| Fumaric Acid SCHEMBL8873443 | 1.00 | HTR2C (0.81) | HTR2CHTR2ALMNAPMP22NPSR1 | |
| Fumaric Acid SCHEMBL8873435 | 1.00 | HTR2C (0.81) | HTR2CHTR2ALMNAPMP22NPSR1 | |
| Fumaric Acid SCHEMBL8875709 | 1.00 | HTR2C (0.81) | HTR2CHTR2ALMNAPMP22NPSR1 | |
| Fumaric Acid SCHEMBL8874759 | 1.00 | HTR2C (0.81) | HTR2CHTR2ALMNAPMP22NPSR1 | |
| Fumaric Acid SCHEMBL8873448 | 0.94 | HTR2C (0.81) | HTR2CHTR2ALMNAPMP22NPSR1 | |
| Fumaric Acid SCHEMBL8873441 | 0.94 | HTR2C (0.81) | HTR2CHTR2ALMNAPMP22NPSR1 | |
| Fumaric Acid SCHEMBL8875027 | 0.92 | HTR2C (0.67) | HTR2CHTR2ALMNAPMP22NPSR1 | |
| Fumaric Acid SCHEMBL8875032 | 0.92 | HTR2C (0.67) | HTR2CHTR2ALMNAPMP22NPSR1 | |
| Fumaric Acid SCHEMBL8872866 | 0.92 | HTR2C (0.67) | HTR2CHTR2ALMNAPMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |