Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 3/20 | 0.44 |
| ▸ | MAX | P61244 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.42 |
| ▸ | EP300 | Q09472 | 3/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886246 | 0.89 | XDH (0.44) | XDHMYCMAXARPELP1 | |
| SCHEMBL8875662 | 0.88 | XDH (0.51) | XDHMYCMAXRXRAPPARG | |
| SCHEMBL8874902 | 0.82 | CA12 (0.49) | HIF1AKDM4EMAPK1L3MBTL1 | |
| SCHEMBL8103054 | 0.80 | XDH (0.46) | XDHMYCMAXRXRAPPARG | |
| SCHEMBL8883400 | 0.78 | CYP2C9 (0.50) | XDHMYCMAXRXRAPPARG | |
| SCHEMBL16319100 | 0.76 | AR (0.44) | XDHARPELP1HIF1AKDM4E | |
| SCHEMBL8882778 | 0.76 | XDH (0.46) | XDHHCAR3NR1H4KDM4EMAPK1 | |
| SCHEMBL8882657 | 0.74 | XDH (0.53) | XDHRXRARARBNR1H4KDM4E | |
| SCHEMBL8883897 | 0.73 | KDM4E (0.47) | HCAR3KDM4EMAPK1L3MBTL1HCAR2 | |
| SCHEMBL28088519 | 0.73 | KDM4E (0.50) | PPARGHCAR3KDM4EMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620996-A | Sulfonamidocarbonyl pyridine-2-carboxesteramides and their pyridine-N-oxide compounds and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |
| US-5610172-A | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-11 | — | — | US | disclosed |