Sugi Predict

Sugi Predict / Compounds / SCHEMBL887519

SCHEMBL887519

SCHEMBL887519

C=CCO[C@@H]1C[C@H](n2cnc3c(N)ncnc32)O[C@@H]1CO

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADA P00813 1/20 0.53
▸ ADORA3 P0DMS8 3/20 0.51
▸ ADORA1 P30542 2/20 0.51
▸ ADORA2A P29274 2/20 0.51
▸ SMN1; SMN2 Q16637 2/20 0.51
▸ PI4KA P42356 2/20 0.51
▸ PI4K2B Q8TCG2 2/20 0.51
▸ PI4K2A Q9BTU6 2/20 0.51
▸ PI4KB Q9UBF8 2/20 0.51
▸ DPP4 P27487 1/20 0.51
▸ MEN1 O00255 1/20 0.51
▸ SLC28A1 O00337 1/20 0.51
▸ MAP3K7 O43318 1/20 0.51
▸ SLC28A2 O43868 1/20 0.51
▸ GAPDH P04406 1/20 0.51
▸ MAPK1 P28482 1/20 0.51
▸ ADORA2B P29275 1/20 0.51
▸ STAT6 P42226 1/20 0.51
▸ KMT2A Q03164 1/20 0.51
▸ DOT1L Q8TEK3 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL427292 1.00 ADA (0.53) ADAADORA3ADORA1ADORA2ASMN1; SMN2
SCHEMBL427293 1.00 ADA (0.53) ADAADORA3ADORA1ADORA2ASMN1; SMN2
SCHEMBL16359958 0.87 GAA (0.61) ADAADORA3ADORA1ADORA2ASMN1; SMN2
SCHEMBL4580720 0.85 ADA (0.58) ADAADORA3ADORA1ADORA2ASMN1; SMN2
SCHEMBL10446527 0.85 ADA (0.58) ADAADORA3ADORA1ADORA2ASMN1; SMN2
SCHEMBL4580716 0.85 ADA (0.58) ADAADORA3ADORA1ADORA2ASMN1; SMN2
SCHEMBL16360128 0.84 ADA (0.57) ADAADORA3ADORA1ADORA2ASMN1; SMN2
SCHEMBL22300661 0.84 ADA (0.57) ADAADORA3ADORA1ADORA2ASMN1; SMN2
SCHEMBL15832423 0.84 ADA (0.57) ADAADORA3ADORA1ADORA2ASMN1; SMN2
SCHEMBL10432419 0.84 ADA (0.57) ADAADORA3ADORA1ADORA2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10000801-B2 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-06-19 — — US disclosed
US-10000801-B2 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-06-19 — — US disclosed
US-20170114403-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-04-27 — — US disclosed
US-20170114403-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-04-27 — — US disclosed
US-9528151-B2 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2016-12-27 — — US disclosed
US-20140315191-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2014-10-23 — — US disclosed
US-20130280700-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2013-10-24 — — US disclosed
US-7883869-B2 for sequencing single-stranded DNA by employing a nanopore and modified nucleotides THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2011-02-08 — — US disclosed
US-20100092952-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-15 — — US disclosed