Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875295 | 1.00 | APP (0.36) | APPTAAR1HTR2AHSP90AA1KMT2A | |
| SCHEMBL8876639 | 0.93 | APP (0.32) | APPHSP90AA1KMT2AIDO1 | |
| SCHEMBL2832485 | 0.89 | APP (0.44) | APPIDO1 | |
| SCHEMBL8875016 | 0.84 | KMT2A (0.33) | HSP90AA1KMT2A | |
| SCHEMBL8875020 | 0.84 | KMT2A (0.33) | HSP90AA1KMT2A | |
| SCHEMBL8875013 | 0.84 | KMT2A (0.33) | HSP90AA1KMT2A | |
| SCHEMBL8876633 | 0.81 | CYP24A1 (0.33) | — | |
| SCHEMBL8876629 | 0.81 | CYP24A1 (0.33) | — | |
| SCHEMBL5565683 | 0.81 | APP (0.38) | APPIDO1 | |
| SCHEMBL12973288 | 0.79 | MME (0.33) | APPIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633373-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1997-05-27 | — | — | US | disclosed |
| EP-0407212-B1 | Enantioselective synthesis of antifolates | LILLY CO ELI (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5516776-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1996-05-14 | — | — | US | disclosed |
| US-5159090-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5008391-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0407212-A1 | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1991-01-09 | — | — | EP | disclosed |