Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875013 | 1.00 | KMT2A (0.33) | KMT2AHSP90AA1POLBCTDSP1PPARD | |
| SCHEMBL8875020 | 1.00 | KMT2A (0.33) | KMT2AHSP90AA1POLBCTDSP1PPARD | |
| SCHEMBL6506348 | 0.86 | KMT2A (0.40) | KMT2AHSP90AA1POLBCTDSP1KDM4E | |
| SCHEMBL8875295 | 0.84 | APP (0.36) | KMT2AHSP90AA1 | |
| SCHEMBL8875302 | 0.84 | APP (0.36) | KMT2AHSP90AA1 | |
| SCHEMBL8876633 | 0.81 | CYP24A1 (0.33) | — | |
| SCHEMBL8876629 | 0.81 | CYP24A1 (0.33) | — | |
| SCHEMBL8876639 | 0.80 | APP (0.32) | KMT2AHSP90AA1POLB | |
| SCHEMBL8874714 | 0.79 | KMT2A (0.38) | KMT2AHSP90AA1POLBCTDSP1KDM4E | |
| SCHEMBL8874702 | 0.79 | KMT2A (0.38) | KMT2AHSP90AA1POLBCTDSP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633373-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1997-05-27 | — | — | US | disclosed |
| EP-0407212-B1 | Enantioselective synthesis of antifolates | LILLY CO ELI (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5516776-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1996-05-14 | — | — | US | disclosed |
| US-5159090-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5008391-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0407212-A1 | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1991-01-09 | — | — | EP | disclosed |