Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.78 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.78 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.78 |
| ▸ | DRD3 | P35462 | 9/20 | 0.62 |
| ▸ | DRD2 | P14416 | 10/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8877020 | 0.98 | HTR1A (0.76) | HTR1AADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL8874517 | 0.93 | HTR1A (0.77) | HTR1AADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL8877526 | 0.92 | HTR1A (0.75) | HTR1AADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL8875092 | 0.90 | HTR1A (0.82) | HTR1AADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL8877282 | 0.90 | HTR1A (0.73) | HTR1AADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL9567529 | 0.90 | HTR1A (0.73) | HTR1AADRA1DADRA1AADRA1BDRD3 | |
| Upidosin SCHEMBL6638869 | 0.88 | HTR1A (1.00) | HTR1AADRA1DADRA1AADRA1BDRD3 | |
| Upidosin SCHEMBL29387625 | 0.88 | HTR1A (1.00) | HTR1AADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL8875957 | 0.87 | HTR1A (0.77) | HTR1AADRA1DADRA1AADRA1BDRD3 | |
| Upidosin SCHEMBL8875378 | 0.86 | HTR1A (0.97) | HTR1AADRA1DADRA1AADRA1BDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | claimed |