Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.33 |
| ▸ | RARA | P10276 | 3/20 | 0.33 |
| ▸ | RARB | P10826 | 3/20 | 0.33 |
| ▸ | RARG | P13631 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 4/20 | 0.31 |
| ▸ | RXRB | P28702 | 4/20 | 0.31 |
| ▸ | RXRG | P48443 | 4/20 | 0.31 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877092 | 0.90 | CYP3A4 (0.33) | CYP3A4CYP26A1RARARARBRARG | |
| SCHEMBL8864897 | 0.88 | RARA (0.38) | CYP3A4RARARARBRARGKMT2A | |
| SCHEMBL6664858 | 0.84 | CYP26A1 (0.46) | FFAR1CYP3A4CYP26A1RARARARB | |
| SCHEMBL8875276 | 0.84 | CYP3A4 (0.45) | FFAR1CYP3A4CYP26A1RARARARB | |
| SCHEMBL8876257 | 0.84 | PTGDR2 (0.34) | CYP3A4CYP26A1RARARARBRARG | |
| SCHEMBL8875070 | 0.82 | CYP3A4 (0.32) | CYP3A4CYP26A1RARARARBRARG | |
| SCHEMBL8874466 | 0.81 | CYP26A1 (0.38) | FFAR1CYP3A4CYP26A1RARARARB | |
| SCHEMBL8865174 | 0.81 | CYP3A4 (0.36) | FFAR1CYP3A4RARARARBRARG | |
| SCHEMBL8865711 | 0.81 | RARA (0.38) | CYP3A4RARARARBRARGKMT2A | |
| SCHEMBL8864880 | 0.80 | RARA (0.33) | CYP3A4RARARARBRARGKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616597-A | ANTIACNE, ANTIPSORIASIS COMPOUNDS | ALLERGAN (US) | 1997-04-01 | — | — | US | disclosed |
| US-5599819-A | SKIN DISORDERS | ALLERGAN | 1997-02-04 | — | — | US | disclosed |
| US-5534516-A | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1, 2, 3, 4-tetrahydroquinolinyl group having retinoid-like activity | ALLERGAN | 1996-07-09 | — | — | US | disclosed |
| EP-0419130-B1 | Acetylenes disubstituted with a heteroaromatic group and A 2-substituted chromanyl, thiochromanyl or 1,2,3,4- tetrahydroquinolinyl group having retinoid-like activity | ALLERGAN INC (US) | 1995-11-15 | — | — | EP | disclosed |
| US-5407937-A | Skin disorders, skin cancer | ALLERGAN, INC. (US) | 1995-04-18 | — | — | US | disclosed |
| US-5272156-A | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity | ALLERGAN, INC. (US) | 1993-12-21 | — | — | US | disclosed |
| US-5183827-A | Skin disorders | ALLERGAN, INC. (US) | 1993-02-02 | — | — | US | disclosed |
| US-5045551-A | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity | ALLERGAN, INC. (US) | 1991-09-03 | — | — | US | disclosed |
| EP-0419130-A2 | Acetylenes disubstituted with a heteroaromatic group and A 2-substituted chromanyl, thiochromanyl or 1,2,3,4- tetrahydroquinolinyl group having retinoid-like activity | ALLERGAN, INC. (US) | 1991-03-27 | — | — | EP | disclosed |