Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8876614 | 0.99 | HTR1A (0.65) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8875423 | 0.95 | HTR1A (0.71) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876208 | 0.94 | HTR1A (0.68) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876340 | 0.93 | HTR1A (0.68) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8875249 | 0.93 | HTR1A (0.70) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8877338 | 0.86 | HTR1A (0.67) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876391 | 0.85 | HTR1A (0.61) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Hydrochloric Acid SCHEMBL8875859 | 0.85 | HTR1A (0.66) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876459 | 0.85 | HTR1A (0.66) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8877818 | 0.85 | HTR1A (0.69) | HTR1AADRA1DADRA1AADRA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |
| US-5403842-A | Adrenergic blocking and antiserotonine agents; urogenital disorders including spasms of the urethral tract and prostrate problems | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-04-04 | — | — | US | claimed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | claimed |