Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | STAT6 | P42226 | 1/20 | 0.62 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8878019 | 0.99 | CYP3A4 (0.61) | CYP3A4CYP1A2CYP2D6CYP2C19STAT6 | |
| SCHEMBL27350528 | 0.83 | CYP3A4 (0.49) | CYP3A4CYP1A2CYP2D6CYP2C19STAT6 | |
| SCHEMBL5118184 | 0.81 | LMNA (0.54) | CYP3A4CYP1A2CYP2D6CYP2C19HTT | |
| SCHEMBL3691280 | 0.81 | SLC11A2 (0.82) | CYP3A4CYP1A2CYP2D6CYP2C19STAT6 | |
| SCHEMBL8874632 | 0.80 | LMNA (0.50) | CYP3A4CYP1A2CYP2D6CYP2C19HTT | |
| Bromide SCHEMBL4154083 | 0.80 | SLC11A2 (0.80) | CYP3A4CYP1A2CYP2D6CYP2C19STAT6 | |
| SCHEMBL14266220 | 0.80 | LMNA (0.55) | CYP3A4CYP1A2CYP2D6CYP2C19HTT | |
| SCHEMBL8875368 | 0.78 | GLA (0.63) | CYP3A4CYP1A2CYP2D6CYP2C19HTT | |
| SCHEMBL8875996 | 0.78 | LMNA (0.44) | CYP3A4CYP1A2CYP2D6CYP2C19STAT6 | |
| SCHEMBL5116298 | 0.78 | LMNA (0.50) | CYP3A4CYP1A2CYP2D6CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | disclosed |
| US-5474994-A | Treating hypertension, urethral and lower urinary tract contractions | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-12-12 | — | — | US | disclosed |
| EP-0566288-B1 | Flavone derivatives | RECORDATI CHEM PHARM (CH) | 1995-08-02 | — | — | EP | disclosed |
| US-5403842-A | Adrenergic blocking and antiserotonine agents; urogenital disorders including spasms of the urethral tract and prostrate problems | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-04-04 | — | — | US | disclosed |
| EP-0566288-A1 | Flavone derivatives | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993017007-A1 | HETEROBICYCLIC COMPOUNDS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 1993-09-02 | — | — | WO | disclosed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | disclosed |