Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.89 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.89 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.89 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 6/20 | 0.59 |
| ▸ | DRD2 | P14416 | 5/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875338 | 0.94 | HTR1A (0.97) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876438 | 0.94 | HTR1A (0.91) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8875563 | 0.94 | HTR1A (0.91) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Upidosin SCHEMBL29387625 | 0.94 | HTR1A (1.00) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Upidosin SCHEMBL6638869 | 0.94 | HTR1A (1.00) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8875767 | 0.93 | HTR1A (0.77) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876307 | 0.93 | HTR1A (0.90) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8874953 | 0.93 | HTR1A (0.90) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Upidosin SCHEMBL8875369 | 0.93 | HTR1A (0.97) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Upidosin SCHEMBL8875378 | 0.93 | HTR1A (0.97) | HTR1AADRA1DADRA1AADRA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |