Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.71 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 7/20 | 0.59 |
| ▸ | DRD4 | P21917 | 7/20 | 0.59 |
| ▸ | DRD3 | P35462 | 7/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | DRD1 | P21728 | 2/20 | 0.59 |
| ▸ | DRD5 | P21918 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875111 | 0.97 | HTR1A (0.67) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8876770 | 0.89 | HTR1A (0.68) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8877818 | 0.89 | HTR1A (0.69) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| Hydrochloric Acid SCHEMBL8874106 | 0.88 | HTR1A (0.67) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8876462 | 0.88 | HTR1A (0.67) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| Hydrochloric Acid SCHEMBL8875648 | 0.88 | HTR1A (0.69) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8875435 | 0.88 | HTR1A (0.71) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8879180 | 0.87 | HTR1A (0.91) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| Hydrochloric Acid SCHEMBL8875518 | 0.86 | HTR1A (0.88) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| Hydrochloric Acid SCHEMBL8875523 | 0.86 | HTR1A (0.88) | HTR1AADRA1AADRA1DADRA1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |
| US-5403842-A | Adrenergic blocking and antiserotonine agents; urogenital disorders including spasms of the urethral tract and prostrate problems | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-04-04 | — | — | US | claimed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | claimed |