Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.33 |
| ▸ | PPARA | Q07869 | 5/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879106 | 0.92 | PPARG (0.33) | PPARGPPARASQOR | |
| SCHEMBL8877833 | 0.90 | HMGCR (0.32) | — | |
| SCHEMBL8878790 | 0.89 | HMGCR (0.38) | KDM4EALDH1A1HPGDSQOR | |
| SCHEMBL8878156 | 0.86 | HMGCR (0.35) | — | |
| SCHEMBL8879656 | 0.86 | MEN1 (0.32) | — | |
| SCHEMBL8878938 | 0.85 | HMGCR (0.33) | — | |
| SCHEMBL8878140 | 0.85 | CHEK1 (0.31) | — | |
| SCHEMBL8877684 | 0.84 | GCGR (0.32) | — | |
| SCHEMBL8876647 | 0.84 | HMGCR (0.37) | KDM4EHPGD | |
| SCHEMBL8875965 | 0.84 | MEN1 (0.38) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |