Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877188 | 0.96 | HMGCR (0.42) | HMGCRKDM4ENPSR1HTTL3MBTL1 | |
| SCHEMBL8901879 | 0.92 | HMGCR (0.36) | HMGCRKDM4ENPSR1HTTL3MBTL1 | |
| SCHEMBL8878790 | 0.88 | HMGCR (0.38) | HMGCRKDM4ENPSR1LMNAHPGD | |
| SCHEMBL8878938 | 0.88 | HMGCR (0.33) | HMGCR | |
| SCHEMBL8878156 | 0.87 | HMGCR (0.35) | HMGCR | |
| SCHEMBL8877833 | 0.86 | HMGCR (0.32) | HMGCR | |
| SCHEMBL8876998 | 0.85 | HMGCR (0.38) | HMGCR | |
| SCHEMBL8876573 | 0.85 | VCP (0.35) | HMGCRKDM4ENPSR1LMNAHPGD | |
| SCHEMBL8877684 | 0.85 | GCGR (0.32) | HMGCR | |
| SCHEMBL8875965 | 0.84 | MEN1 (0.38) | KDM4ENPSR1L3MBTL1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |