Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.50 |
| ▸ | DHODH | Q02127 | 7/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 3/20 | 0.42 |
| ▸ | LDHB | P07195 | 2/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10467326 | 0.80 | DHODH (0.59) | PDE10ADHODHTSHRKMT2AMEN1 | |
| SCHEMBL26617556 | 0.79 | PDE10A (0.62) | PDE10ADHODHTSHRKMT2AMEN1 | |
| SCHEMBL13451644 | 0.79 | PDE10A (0.41) | PDE10ADHODHTSHRKMT2AMEN1 | |
| SCHEMBL8878762 | 0.78 | ERN1 (0.53) | PDE10ADHODHKMT2AMEN1LMNA | |
| SCHEMBL8879814 | 0.77 | GCGR (0.41) | TSHRKMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL14106730 | 0.76 | PDE10A (0.72) | PDE10ADHODHTSHRKMT2AMEN1 | |
| SCHEMBL1102408 | 0.76 | KDM4E (0.50) | TSHRKMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL14506258 | 0.75 | ATM (0.38) | PDE10ADHODHTSHRKMT2AMEN1 | |
| SCHEMBL14533531 | 0.75 | GCGR (0.43) | TSHRKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL2534987 | 0.75 | PDE10A (0.49) | PDE10ADHODHTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0444533-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |