Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.68 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8875719 | 0.96 | HTR1A (0.65) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876440 | 0.95 | HTR1A (0.65) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8877240 | 0.93 | HTR1A (0.68) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8875103 | 0.92 | HTR1A (0.63) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Hydrochloric Acid SCHEMBL8874623 | 0.92 | HTR1A (0.67) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8877086 | 0.88 | HTR1A (0.68) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Hydrochloric Acid SCHEMBL8876084 | 0.87 | HTR1A (0.66) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8875323 | 0.84 | HTR1A (0.65) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876921 | 0.84 | HTR1A (0.75) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876556 | 0.84 | HTR1A (0.75) | HTR1AADRA1DADRA1AADRA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |
| US-5403842-A | Adrenergic blocking and antiserotonine agents; urogenital disorders including spasms of the urethral tract and prostrate problems | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-04-04 | — | — | US | claimed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | claimed |