Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.42 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DTYMK | P23919 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18181191 | 0.86 | POLB (0.43) | POLBGPR119GRM5GRM1MAPK1 | |
| SCHEMBL4598286 | 0.85 | POLB (0.43) | POLBGPR119GRM5GRM1MAPK1 | |
| SCHEMBL14097932 | 0.85 | POLB (0.43) | POLBGPR119GRM5GRM1MAPK1 | |
| SCHEMBL17094798 | 0.84 | POLB (0.42) | POLBGPR119GRM5GRM1MAPK1 | |
| SCHEMBL17094785 | 0.83 | POLB (0.41) | POLBGPR119GRM5GRM1MAPK1 | |
| SCHEMBL17094830 | 0.82 | PTPN1 (0.42) | POLBGPR119GRM5GRM1MAPK1 | |
| Lithium Ion SCHEMBL17094797 | 0.82 | POLB (0.40) | POLBGPR119GRM5GRM1MAPK1 | |
| SCHEMBL18181042 | 0.81 | POLB (0.40) | POLBGPR119GRM5GRM1MAPK1 | |
| SCHEMBL20024837 | 0.80 | POLB (0.39) | POLBGPR119GRM5GRM1MAPK1 | |
| SCHEMBL4597401 | 0.79 | NR1D1 (0.40) | POLBGPR119GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681959-A | DEPROTONATION OF A 2-AMINO-3-ALKYLPYRIDINE WITH AN ALKYLLITHIUM COMPOUND, THEN REACTION WITH AN AMIDE OR ESTER AND TREATMENT WITH A CONCENTRATED ACID FOR CYCLIZATION | MERCK, SHARP & DOHME LTD. (GB) | 1997-10-28 | — | — | US | disclosed |