Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.39 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879132 | 0.92 | HMGCR (0.41) | HMGCRSQORKDM4EALDH1A1LMNA | |
| SCHEMBL8902033 | 0.90 | HMGCR (0.34) | HMGCRHPGD | |
| SCHEMBL8877411 | 0.87 | HMGCR (0.40) | HMGCRSQOR | |
| SCHEMBL8900012 | 0.84 | DHODH (0.36) | — | |
| SCHEMBL8877078 | 0.84 | HMGCR (0.39) | HMGCRSQORKDM4EALDH1A1LMNA | |
| SCHEMBL8902222 | 0.83 | GCGR (0.38) | — | |
| SCHEMBL8877642 | 0.82 | HMGCR (0.35) | HMGCRHPGD | |
| SCHEMBL8877739 | 0.79 | HMGCR (0.41) | HMGCRSQOR | |
| SCHEMBL8878790 | 0.78 | HMGCR (0.38) | HMGCRSQORKDM4EALDH1A1LMNA | |
| SCHEMBL8877505 | 0.78 | HMGCR (0.40) | HMGCRSQORKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |