SCHEMBL8878352

SCHEMBL8878352

CC(=O)C=Cc1c(C)c(C)c2c(c1C)CC(C)(C)O2

nearest known ligand 0.32

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
TSHR P16473 1/20 0.32
ALDH1A1 P00352 2/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
MAPT P10636 1/20 0.31
EZH2 Q15910 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8878346 1.00 PTGS1 (0.32) PTGS1PTGS2CYP1A2CYP3A4TSHR
SCHEMBL8877836 0.94 ALDH1A1 (0.31) ALDH1A1MEN1KMT2AMAPTEZH2
SCHEMBL8877840 0.94 ALDH1A1 (0.31) ALDH1A1MEN1KMT2AMAPTEZH2
SCHEMBL8878550 0.88 ALDH1A1 (0.31) ALDH1A1MEN1KMT2AMAPTEZH2
SCHEMBL8878562 0.88 ALDH1A1 (0.31) ALDH1A1MEN1KMT2AMAPTEZH2
SCHEMBL8877911 0.85 ALDH1A1 (0.31) CYP1A2CYP3A4ALDH1A1
SCHEMBL8877915 0.85 ALDH1A1 (0.31) CYP1A2CYP3A4ALDH1A1
SCHEMBL8878018 0.78 ALDH1A1 (0.34) PTGS1PTGS2CYP1A2CYP3A4TSHR
SCHEMBL8074416 0.76 MAPT (0.33) ALDH1A1MEN1KMT2AMAPT
SCHEMBL8074415 0.76 MAPT (0.33) ALDH1A1MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5631208-A Herbicidal cyclohexane-1,3-dione derivatives and their preparation process KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1997-05-20 US disclosed
WO-1994003443-A1 HERBICIDAL CYCLOHEXANE-1,3-DIONE DERIVATIVES AND THEIR PREPARATION PROCESS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1994-02-17 WO disclosed