Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.59 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.56 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611388 | 0.88 | GPBAR1 (0.62) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8648447 | 0.87 | GPBAR1 (0.60) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL9431747 | 0.86 | GPBAR1 (0.59) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL10410134 | 0.85 | CYSLTR1 (0.58) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL10410628 | 0.85 | GPBAR1 (0.58) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8880806 | 0.83 | CYSLTR1 (0.58) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL10410185 | 0.83 | GPBAR1 (0.56) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL9498311 | 0.83 | ALOX5 (0.54) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL9589932 | 0.82 | ALOX5 (0.66) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL7801682 | 0.82 | ALOX5 (0.66) | GPBAR1CYSLTR1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597833-A | LEUKOTRIENE SYNTHESIS INHIBITORS FOR ANTIINFLAMMATORY AGENTS, RESPIRATORY SYSTEM DISORDERS, ANTIALLERGENS OR ANTIISCHEMIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-01-28 | — | — | US | disclosed |
| CN-1087337-A | The quinolin-2-ylmethoxy phenylacetic acid derivatives that replaces | BAYER AG (DE) | 1994-06-01 | — | — | CN | disclosed |