Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8781669 | 0.93 | NPC1 (0.53) | NPC1RAB9APDE3BPDE3AP2RY12 | |
| SCHEMBL8880502 | 0.89 | NPC1 (0.65) | NPC1RAB9APDE3BPDE3AP2RY12 | |
| SCHEMBL8881016 | 0.88 | NPC1 (0.67) | NPC1RAB9APDE3BPDE3AP2RY12 | |
| SCHEMBL8785064 | 0.83 | NPC1 (0.55) | NPC1RAB9APDE3BPDE3AP2RY12 | |
| SCHEMBL9346993 | 0.81 | NPC1 (0.56) | NPC1RAB9APDE3BPDE3AP2RY12 | |
| SCHEMBL12932018 | 0.78 | NPC1 (0.94) | NPC1RAB9APDE3BPDE3AP2RY12 | |
| SCHEMBL15310176 | 0.76 | NPC1 (1.00) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL10439126 | 0.74 | NPC1 (0.58) | NPC1RAB9APDE3BPDE3AP2RY12 | |
| SCHEMBL8781836 | 0.74 | THRB (0.48) | NPC1RAB9APDE3BPDE3AP2RY12 | |
| SCHEMBL27951169 | 0.73 | MAPT (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614521-A | NERVE GROWTH FACTOR | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | claimed |
| CN-1064273-A | The new NGF that has generates the active benzene derivative of promotion | SANKYO CO (JP) | 1992-09-09 | — | — | CN | claimed |
| EP-0501656-A2 | New benzene derivatives having (NGF) production-promoting activity | Sankyo Company Limited (JP) | 1992-09-02 | — | — | EP | claimed |