Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 10/20 | 0.43 |
| ▸ | RHOA | P61586 | 10/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | CLPP | Q16740 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8069509 | 1.00 | RHOC (0.43) | RHOCRHOAUTS2RTACR1P2RX1 | |
| SCHEMBL8062563 | 0.90 | TACR1 (0.39) | TACR1 | |
| SCHEMBL8565826 | 0.89 | MCHR1 (0.42) | RHOCRHOAUTS2RTACR1 | |
| SCHEMBL8882416 | 0.89 | MCHR1 (0.42) | RHOCRHOAUTS2RTACR1 | |
| SCHEMBL8878961 | 0.83 | UTS2R (0.37) | UTS2R | |
| SCHEMBL8559422 | 0.83 | UTS2R (0.37) | UTS2R | |
| SCHEMBL8063644 | 0.80 | TACR1 (0.43) | TACR1 | |
| SCHEMBL8332703 | 0.76 | TACR1 (0.56) | RHOCRHOAUTS2RTACR1P2RX1 | |
| SCHEMBL8560072 | 0.75 | MCHR1 (0.39) | RHOCRHOATACR1P2RX1 | |
| SCHEMBL8560068 | 0.75 | MCHR1 (0.39) | RHOCRHOATACR1P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607936-A | USEFUL IN TREATMENT OF RESPIRATORY DISEASES | MERCK & CO., INC. (US) | 1997-03-04 | — | — | US | disclosed |
| WO-1996010568-A1 | SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1996-04-11 | — | — | WO | disclosed |