Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.69 |
| ▸ | HTR1B | P28222 | 14/20 | 0.69 |
| ▸ | HTR1D | P28221 | 12/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879715 | 0.99 | HTR1A (0.67) | HTR1AHTR1BHTR1DMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL8882075 | 0.98 | MAPT (0.66) | HTR1AHTR1BHTR1DMAPTMEN1 | |
| SCHEMBL8880990 | 0.96 | MAPT (0.69) | HTR1AHTR1BHTR1DMAPTMEN1 | |
| SCHEMBL8880777 | 0.93 | HTR1A (0.66) | HTR1AHTR1BHTR1DMAPTMEN1 | |
| SCHEMBL8879233 | 0.91 | HTR1A (0.63) | HTR1AHTR1BHTR1DMAPTMEN1 | |
| SCHEMBL8878119 | 0.90 | HTR1A (0.61) | HTR1AHTR1BHTR1DMAPTMEN1 | |
| SCHEMBL8880288 | 0.90 | HTR1A (0.63) | HTR1AHTR1BHTR1DMAPTMEN1 | |
| SCHEMBL8880295 | 0.87 | HTR1A (0.59) | HTR1AHTR1BHTR1DMAPTMEN1 | |
| SCHEMBL8880677 | 0.85 | HTR1A (0.65) | HTR1AHTR1BHTR1DMAPTMEN1 | |
| SCHEMBL5148291 | 0.84 | MAPT (0.70) | HTR1AHTR1BHTR1DMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654431-A | EXHIBIT SELECTIVITY TOWARDS 5-HYDROXYTRYPTAMINE RECEPTORS OF BRAIN CELLS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1997-08-05 | — | — | US | claimed |
| WO-1997046525-A1 | 5-ALKOXY-TRYPTAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR AGONISTS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1997-12-11 | — | — | WO | disclosed |
| US-5654431-A | EXHIBIT SELECTIVITY TOWARDS 5-HYDROXYTRYPTAMINE RECEPTORS OF BRAIN CELLS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1997-08-05 | — | — | US | disclosed |