Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 3/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880304 | 1.00 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL9640983 | 0.85 | POLB (0.56) | POLBSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL10595784 | 0.85 | POLB (0.56) | POLBSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL5345594 | 0.85 | POLB (0.56) | POLBSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL6907072 | 0.85 | POLB (0.52) | POLBSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL31662033 | 0.82 | MEN1 (0.60) | POLBSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7276440 | 0.82 | POLB (0.50) | POLBSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL8691967 | 0.82 | POLB (0.48) | POLBSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL77520 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL29059857 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658928-A | ANTICOAGULANTS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS,WOUND HEALING AGENTS, OSTEOPOROSIS | HOFFMANN-LA ROCHE INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5545658-A | FOR TREATMENT OR PROPHYLAXIS OF ILLNESSES WHICH ARE CAUSED BY THE BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELETS AND BY BLOOD PLATELET AGGREGATION AND CELL-CELL ADHESION | HOFFMAN-LA ROCHE INC. (US) | 1996-08-13 | — | — | US | disclosed |
| US-5378712-A | Antithrombosis | Hoffmann-La Roche Inc (US) | 1995-01-03 | — | — | US | disclosed |