Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 5/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877820 | 0.79 | HMGCR (0.41) | HMGCRDHODHPDE10ACTSA | |
| SCHEMBL8878936 | 0.79 | — | — | |
| SCHEMBL10345295 | 0.77 | HMGCR (0.40) | HMGCRCTSA | |
| SCHEMBL8880612 | 0.77 | HMGCR (0.39) | HMGCRDHODHPDE10APRNPRXFP1 | |
| SCHEMBL8877812 | 0.74 | PDE10A (0.33) | HMGCRDHODHPDE10APRNPRXFP1 | |
| SCHEMBL8953516 | 0.73 | — | — | |
| SCHEMBL8953497 | 0.73 | — | — | |
| SCHEMBL8879913 | 0.71 | HMGCR (0.34) | HMGCR | |
| SCHEMBL8877481 | 0.70 | — | — | |
| SCHEMBL8877788 | 0.69 | PRNP (0.32) | HMGCRPRNPRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |