Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28987859 | 0.87 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTNPC1PKMHDAC8 | |
| SCHEMBL8881365 | 0.83 | NPC1 (0.50) | SMN1; SMN2MAPTNPC1PKMHDAC8 | |
| SCHEMBL9251931 | 0.79 | CYP11B1 (0.52) | SMN1; SMN2MAPTGSK3BMAOAMAOB | |
| SCHEMBL8880708 | 0.79 | HDAC8 (0.60) | SMN1; SMN2MAPTNPC1PKMHDAC8 | |
| SCHEMBL17001607 | 0.76 | MAPT (0.51) | SMN1; SMN2MAPTNPC1PKMGSK3B | |
| SCHEMBL18824399 | 0.75 | HDAC8 (0.56) | MAPTHDAC8GSK3BGAAMEN1 | |
| SCHEMBL2729058 | 0.74 | GSK3B (0.52) | SMN1; SMN2MAPTNPC1PKMGSK3B | |
| SCHEMBL11920163 | 0.73 | ALDH1A1 (0.64) | SMN1; SMN2MAPTNPC1PKMGSK3B | |
| SCHEMBL2662135 | 0.73 | CYP4F2 (0.58) | SMN1; SMN2MAPTNPC1GAA | |
| SCHEMBL28987838 | 0.72 | SMN1; SMN2 (0.80) | SMN1; SMN2MAPTNPC1HDAC8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668159-A | ANTICOAGULANTS FOR CARDIOVASCULAR DISORDERS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-09-16 | — | — | US | disclosed |