Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 11/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8882129 | 0.94 | MAPT (0.34) | MAPTGSK3BAAK1CARM1PRMT6 | |
| SCHEMBL8883675 | 0.91 | GSK3B (0.42) | MAPTGSK3BCNR2CNR1 | |
| SCHEMBL8883898 | 0.88 | KMT2A (0.39) | MAPTGSK3BAAK1CARM1PRMT6 | |
| SCHEMBL8882700 | 0.83 | GRIN3B (0.39) | AAK1 | |
| SCHEMBL8882767 | 0.83 | GRIN3B (0.39) | AAK1 | |
| SCHEMBL8881065 | 0.83 | CNR2 (0.33) | CNR2SCN9A | |
| SCHEMBL8779252 | 0.83 | CARM1 (0.34) | MAPTGSK3BCNR2AAK1CNR1 | |
| SCHEMBL8883971 | 0.82 | CYP3A4 (0.35) | MAPTGSK3BAAK1CYP3A4 | |
| SCHEMBL8883362 | 0.81 | IKBKB (0.38) | MAPTCARM1PRMT6 | |
| SCHEMBL8882922 | 0.81 | IKBKB (0.38) | MAPTCARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620995-A | Substituted heterocyclic carboxyamides, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |