Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | CTSV | O60911 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5583791 | 0.89 | RXRA (0.50) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL3780312 | 0.80 | TDP1 (0.53) | HPGDRAB9A | |
| SCHEMBL5583574 | 0.80 | SRD5A1 (0.47) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL27325990 | 0.79 | ATM (0.49) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8882097 | 0.79 | MRGPRX4 (0.53) | NPC1RAB9ASMN1; SMN2MRGPRX4PKM | |
| SCHEMBL8882605 | 0.79 | SRD5A1 (0.45) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL20616566 | 0.79 | SMN1; SMN2 (0.49) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8882239 | 0.78 | CNR2 (0.45) | HPGDSMPD1PDE4APDE4BPDE4C | |
| SCHEMBL4703419 | 0.78 | SMPD1 (0.48) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL15058040 | 0.77 | MAPT (0.49) | RXRANPC1RAB9ASMN1; SMN2FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658933-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-19 | — | — | US | disclosed |
| CN-1107144-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AG (DE) | 1995-08-23 | — | — | CN | disclosed |