Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.47 |
| ▸ | PLK2 | Q9NYY3 | 9/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 6/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL88828 | 1.00 | PLK1 (0.47) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL74771 | 0.91 | PLK1 (0.53) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL10319396 | 0.83 | PLK1 (0.51) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL30523195 | 0.83 | PLK1 (0.51) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL382821 | 0.83 | PLK1 (0.51) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL92593 | 0.83 | PLK1 (0.51) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL1288242 | 0.81 | PLK1 (0.49) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL1288243 | 0.81 | PLK1 (0.49) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL84917 | 0.81 | PLK1 (0.55) | PLK1PLK2PLK3 | |
| SCHEMBL92591 | 0.80 | PLK1 (0.53) | PLK1PLK2PLK3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129387-B2 | Substituted 5,6-dihydroimidazo[1,5-F]pteridines useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-06 | — | — | US | disclosed |