SCHEMBL8883149

SCHEMBL8883149

O=C(O)CN1C(=O)C(NC(=O)C(S)Cc2ccccc2)=CCc2ccccc21

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACE P12821 17/20 0.56
MME P08473 16/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9227091 1.00 ACE (0.56) ACEMME
SCHEMBL8881495 0.88 MME (0.45) ACEMME
SCHEMBL9226676 0.88 MME (0.45) ACEMME
SCHEMBL8883638 0.75 ACE (0.40) ACEMME
SCHEMBL8882015 0.73 ACE (0.39) ACEMME
SCHEMBL7441045 0.72 ACE (1.00) ACEMME
SCHEMBL6440328 0.72 ACE (1.00) ACEMME
SCHEMBL6440330 0.72 ACE (1.00) ACEMME
SCHEMBL7444571 0.72 ACE (1.00) ACEMME
SCHEMBL7444580 0.72 ACE (1.00) ACEMME

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5679671-A ANGIOTENSIN 1-CONVERTING ENZYME INHIBITOR, VASOPRESSIN ANTAGONISM AND ATRIAL NAUTRIURETIC PEPTIDE HYDROLASE INHIBITOR EISAI CO., LTD. (JP) 1997-10-21 US disclosed