Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.31 |
| ▸ | TARDBP | Q13148 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28674740 | 0.98 | MEN1 (0.52) | TSHRMAPK1KMT2AMEN1GAA | |
| SCHEMBL22266242 | 0.98 | TSHR (0.48) | TSHRMAPK1KMT2AMEN1GAA | |
| SCHEMBL22266235 | 0.93 | GAA (0.52) | TSHRMAPK1KMT2AMEN1GAA | |
| SCHEMBL22266259 | 0.91 | KMT2A (0.50) | TSHRMAPK1KMT2AMEN1GAA | |
| SCHEMBL8881923 | 0.91 | GAA (0.55) | TSHRMAPK1KMT2AMEN1GAA | |
| SCHEMBL22266293 | 0.91 | GAA (0.55) | TSHRMAPK1KMT2AMEN1GAA | |
| SCHEMBL22266241 | 0.91 | TSHR (0.46) | TSHRMAPK1KMT2AMEN1GAA | |
| Triethylene Glycol SCHEMBL8995564 | 0.90 | MEN1 (0.55) | TSHRMAPK1KMT2AMEN1GAA | |
| SCHEMBL22266240 | 0.90 | GAA (0.48) | TSHRMAPK1KMT2AMEN1GAA | |
| SCHEMBL27819968 | 0.89 | GAA (0.40) | TSHRMAPK1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11833208-B2 | PLK1 selective degradation inducing compound | UPPTHERA, INC. (KR) | 2023-12-05 | — | — | US | disclosed |
| US-20230104076-A1 | PLK1 Selective Degradation Inducing Compound | UPPTHERA INC. (KR) | 2023-04-06 | — | — | US | disclosed |
| US-10723717-B2 | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides | ARVINAS OPERATIONS, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-5658933-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-19 | — | — | US | disclosed |
| US-4325973-A | Hydroxyalkyl amides as fungicides to eumycotina in phanerogamia plant life | GAF CORPORATION (US) | 1982-04-20 | — | — | US | disclosed |
| US-4195096-A | NONTOXIC, BIODEGRADABLE | GAF CORPORATION (US) | 1980-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230104076-A1 | PLK1 Selective Degradation Inducing Compound | PLK1, BUB1B, BUB1 | TSHR 4252/4885MAPK1 1316/4885KMT2A 928/4885 |
| US-11833208-B2 | PLK1 selective degradation inducing compound | PLK1, BUB1B, BUB1 | TSHR 4252/4885MAPK1 1316/4885KMT2A 928/4885 |
| US-10723717-B2 | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides | CRBN, ARAF, VHL | TSHR 2304/4885MAPK1 2843/4885KMT2A 1975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.