Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HPRT1 | P00492 | 12/20 | 0.60 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.52 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.52 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
| ▸ | PNP | P00491 | 3/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8896849 | 0.99 | POLB (0.62) | POLBHPRT1P2RY2P2RY4P2RY6 | |
| SCHEMBL16503343 | 0.83 | POLB (0.64) | POLBHPRT1P2RY2P2RY4P2RY6 | |
| SCHEMBL16509553 | 0.83 | POLB (0.64) | POLBHPRT1P2RY2P2RY4P2RY6 | |
| SCHEMBL8897427 | 0.83 | NT5E (0.65) | HPRT1NT5ETGM2 | |
| SCHEMBL3759846 | 0.82 | HPRT1 (0.61) | POLBHPRT1P2RY2P2RY4P2RY6 | |
| SCHEMBL2231785 | 0.82 | POLB (0.81) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL12154664 | 0.82 | HPRT1 (0.61) | POLBHPRT1P2RY2P2RY4P2RY6 | |
| SCHEMBL12151598 | 0.82 | HPRT1 (0.61) | POLBHPRT1P2RY2P2RY4P2RY6 | |
| SCHEMBL25171429 | 0.81 | POLB (0.82) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL1971161 | 0.81 | POLB (0.82) | POLBP2RY2P2RY4P2RY6NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398231-B1 | Nucleoside analogs | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 1997-07-16 | — | — | EP | claimed |
| US-5693798-A | ACTIVE AGAINST RETROVIRAL DISEASES; PROPHYLAXIS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-12-02 | — | — | US | disclosed |
| US-5686611-A | Nucleoside analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-11-11 | — | — | US | disclosed |
| EP-0398231-B1 | Nucleoside analogs | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 1997-07-16 | — | — | EP | disclosed |