Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 11/20 | 0.47 |
| ▸ | RXRA | P19793 | 10/20 | 0.47 |
| ▸ | RXRG | P48443 | 8/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881005 | 0.85 | MRGPRX4 (0.47) | RXRBRXRARXRGMRGPRX4NPC1 | |
| SCHEMBL8882048 | 0.81 | MAPT (0.36) | RXRBRXRARXRGP4HTMNPC1 | |
| SCHEMBL8882970 | 0.77 | KMT2A (0.36) | RXRBRXRARXRGALDH1A1MEN1 | |
| SCHEMBL27438250 | 0.76 | MEN1 (0.38) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL8883093 | 0.75 | MAPK1 (0.40) | — | |
| SCHEMBL26260122 | 0.75 | PTPN1 (0.53) | RXRBRXRARXRGP4HTMNR4A1 | |
| SCHEMBL8785569 | 0.74 | LTA4H (0.40) | RXRBRXRARXRGP4HTMKDM4E | |
| SCHEMBL23870190 | 0.74 | CXCR2 (0.52) | RXRBRXRARXRGMRGPRX4L3MBTL1 | |
| SCHEMBL30037126 | 0.73 | P4HTM (0.47) | RXRBRXRARXRGP4HTMMRGPRX4 | |
| SCHEMBL25037415 | 0.73 | P4HTM (0.47) | RXRBRXRARXRGP4HTMMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658933-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-19 | — | — | US | disclosed |
| CN-1107144-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AG (DE) | 1995-08-23 | — | — | CN | disclosed |