Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 13/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028652 | 0.95 | EPHX2 (0.44) | TACR1OPRK1OPRD1CNR1MEN1 | |
| SCHEMBL9027567 | 0.94 | MEN1 (0.43) | TACR1OPRK1OPRD1CNR1MEN1 | |
| SCHEMBL8883694 | 0.90 | TACR1 (0.46) | TACR1OPRK1OPRD1CNR1TACR2 | |
| SCHEMBL8882055 | 0.90 | TACR1 (0.46) | TACR1OPRK1OPRD1CNR1TACR2 | |
| SCHEMBL8883348 | 0.89 | TACR1 (0.42) | TACR1OPRK1OPRD1CNR1TACR2 | |
| SCHEMBL8884286 | 0.87 | TACR1 (0.42) | TACR1OPRK1OPRD1CNR1TACR2 | |
| SCHEMBL8884315 | 0.87 | TACR1 (0.42) | TACR1OPRK1OPRD1CNR1TACR2 | |
| SCHEMBL8884136 | 0.87 | TACR1 (0.45) | TACR1OPRK1OPRD1CNR1TACR2 | |
| SCHEMBL8883296 | 0.86 | TACR1 (0.41) | TACR1OPRK1OPRD1CNR1TACR2 | |
| SCHEMBL8882764 | 0.86 | TACR1 (0.41) | TACR1OPRK1OPRD1CNR1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607947-A | Pyrrolidinyl tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0714891-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-06-05 | — | — | EP | disclosed |