Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.56 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 5/20 | 0.52 |
| ▸ | HTR6 | P50406 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8885008 | 1.00 | HTR1B (0.56) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8887126 | 1.00 | HTR1B (0.56) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8790365 | 0.89 | HTR1B (0.61) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8790371 | 0.89 | HTR1B (0.61) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8887494 | 0.87 | HTR1B (0.60) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8888353 | 0.87 | HTR1B (0.59) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8888251 | 0.86 | HTR1B (0.56) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8888071 | 0.86 | HTR1B (0.58) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8888877 | 0.86 | HTR1B (0.58) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL9030786 | 0.86 | HTR1B (0.56) | HTR1BHTR1ACHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639779-A | TREATMENT OF DIFFERENT TYPES OF HEADACHES | PFIZER INC. (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0635014-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LTD (GB) | 1996-01-17 | — | — | EP | disclosed |
| WO-1993021177-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |