Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 8/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | THPO | P40225 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.58 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886654 | 0.89 | PTGER1 (0.65) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8887008 | 0.85 | PTGER1 (0.72) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9857831 | 0.82 | ALDH1A1 (0.73) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8885549 | 0.81 | PTGER1 (0.72) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8887104 | 0.81 | PTGER1 (0.69) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL29468714 | 0.80 | PTGER1 (0.98) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL5944364 | 0.80 | PTGER1 (0.98) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8885367 | 0.79 | PTGER1 (0.70) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL31012289 | 0.79 | PTGER1 (0.96) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL12648484 | 0.79 | MEN1 (1.00) | PTGER1MAPTMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995033733-A1 | SUBSTITUTED DIBENZOXAZEPINE AND DIBENZOTHIAZEPINE UREAS USEFUL AS PROSTAGLANDIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1995-12-14 | — | — | WO | claimed |
| US-5661146-A | ANALGESICS | G.D. SEARLE & CO. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5449675-A | Analgesics | G. D. SEARLE & CO. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5441950-A | Analgesics, prostaglandin E2 antagonists | G. D. SEARLE & CO. (US) | 1995-08-15 | — | — | US | disclosed |