Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 19/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 19/20 | 0.65 |
| ▸ | NQO2 | P16083 | 15/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886502 | 0.93 | MTNR1A (0.62) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL7950141 | 0.91 | MTNR1A (0.79) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL7943795 | 0.91 | MTNR1A (0.79) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8886469 | 0.88 | MTNR1A (0.82) | MTNR1AMTNR1BNQO2HTR2C | |
| SCHEMBL8887708 | 0.85 | MTNR1A (0.83) | MTNR1AMTNR1BNQO2HTR2C | |
| SCHEMBL6265655 | 0.84 | MTNR1A (0.74) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8888092 | 0.84 | MTNR1A (0.83) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL7952293 | 0.84 | MTNR1A (0.74) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8885953 | 0.83 | MTNR1A (0.73) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL4687318 | 0.79 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661186-A | MELATONERGIC EFFECT; CENTRAL NERVOUS SYSTEM DISODERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-08-26 | — | — | US | disclosed |
| EP-0728738-A1 | Tetralinyl- and indanyl-ethylamides having melatonergic activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-28 | — | — | EP | disclosed |