Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275282 | 0.84 | KCNA5 (0.50) | KCNA5KCNH2CYP2D6KCNE1KCNJ5 | |
| SCHEMBL1526122 | 0.84 | KCNA5 (0.50) | KCNA5KCNH2CYP2D6KCNE1KCNJ5 | |
| SCHEMBL8216569 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNATSHRPPARG | |
| SCHEMBL8986648 | 0.79 | KCNA5 (0.49) | KCNA5KCNH2CYP2D6KCNE1KCNJ5 | |
| SCHEMBL7293012 | 0.79 | KCNA5 (0.49) | KCNA5KCNH2CYP2D6KCNE1KCNJ5 | |
| SCHEMBL6000906 | 0.78 | KCNA5 (0.47) | KCNA5KCNH2CYP2D6KCNE1KCNJ5 | |
| Hydrochloric Acid SCHEMBL8608055 | 0.78 | KCNA5 (0.47) | KCNA5KCNH2CYP2D6KCNE1KCNJ5 | |
| SCHEMBL16227724 | 0.78 | KCNA5 (0.47) | KCNA5KCNH2CYP2D6KCNE1KCNJ5 | |
| SCHEMBL28331181 | 0.78 | KCNA5 (0.47) | KCNA5KCNH2CYP2D6KCNE1KCNJ5 | |
| SCHEMBL1971757 | 0.75 | TSHR (0.55) | KCNA5KCNH2CYP2D6KCNE1KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631264-A | NEUROLOGICAL DISORDERS | SANOFI WINTHROP, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5554620-A | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof | STERLING WINTHROP INC. (US) | 1996-09-10 | — | — | US | disclosed |
| EP-0656359-A1 | Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts and compositionsand methods of use thereof | STERLING WINTHROP INC. (US) | 1995-06-07 | — | — | EP | disclosed |