Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.80 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11708769 | 0.89 | KMT2A (1.00) | KMT2ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL220059 | 0.86 | KMT2A (0.72) | KMT2ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL9624375 | 0.86 | KMT2A (0.67) | KMT2ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL8006673 | 0.85 | KMT2A (0.65) | KMT2ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL7869937 | 0.85 | KMT2A (0.65) | KMT2ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL1127360 | 0.85 | KMT2A (0.65) | KMT2ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL20491087 | 0.84 | KMT2A (0.77) | KMT2ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL647703 | 0.83 | TSHR (0.82) | KMT2ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL530857 | 0.83 | KMT2A (0.68) | KMT2ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL16474308 | 0.82 | BDKRB1 (0.62) | KMT2ATSHRALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631264-A | NEUROLOGICAL DISORDERS | SANOFI WINTHROP, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5554620-A | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof | STERLING WINTHROP INC. (US) | 1996-09-10 | — | — | US | disclosed |
| EP-0656359-A1 | Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts and compositionsand methods of use thereof | STERLING WINTHROP INC. (US) | 1995-06-07 | — | — | EP | disclosed |