Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.75 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.75 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889138 | 1.00 | CYSLTR1 (0.75) | CYSLTR1CYSLTR2LTB4RLTB4R2PTGER4 | |
| SCHEMBL8889821 | 1.00 | CYSLTR1 (0.75) | CYSLTR1CYSLTR2LTB4RLTB4R2PTGER4 | |
| SCHEMBL8888465 | 0.92 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2LTB4RLTB4R2 | |
| SCHEMBL8888199 | 0.92 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2LTB4RLTB4R2 | |
| SCHEMBL8888459 | 0.92 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2LTB4RLTB4R2 | |
| SCHEMBL8890460 | 0.85 | CYSLTR1 (0.80) | CYSLTR1CYSLTR2LTB4RLTB4R2PTGER4 | |
| SCHEMBL9212064 | 0.85 | LTB4R (0.55) | CYSLTR1CYSLTR2LTB4RLTB4R2 | |
| SCHEMBL8889488 | 0.85 | LTB4R (0.55) | CYSLTR1CYSLTR2LTB4RLTB4R2 | |
| SCHEMBL8889481 | 0.85 | LTB4R (0.55) | CYSLTR1CYSLTR2LTB4RLTB4R2 | |
| SCHEMBL1223364 | 0.84 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2LTB4RLTB4R2PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0665842-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994008996-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1994-04-28 | — | — | WO | disclosed |