SCHEMBL8889324

SCHEMBL8889324

CSc1cccc(Cl)c1Cc1ccccc1C(=O)c1cnoc1C1CC1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.37
ALDH1A1 P00352 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
CASP3 P42574 1/20 0.37
RAB9A P51151 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
NR1H4 Q96RI1 5/20 0.35
MAPT P10636 2/20 0.33
GAA P10253 1/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32
LMNA P02545 2/20 0.32
PKM P14618 1/20 0.32
RECQL P46063 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
SLC22A12 Q96S37 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8892743 0.93 HPGD (0.38) HPGDALDH1A1SMN1; SMN2CASP3RAB9A
SCHEMBL8889420 0.89 MEN1 (0.38) HPGDALDH1A1SMN1; SMN2CASP3RAB9A
SCHEMBL8891465 0.87 HPGD (0.39) HPGDALDH1A1SMN1; SMN2CASP3RAB9A
SCHEMBL8891589 0.87 DHODH (0.35) HPGDALDH1A1SMN1; SMN2CASP3RAB9A
SCHEMBL8890525 0.85 HPGD (0.39) HPGDALDH1A1SMN1; SMN2CASP3RAB9A
SCHEMBL8890546 0.84 NR1H4 (0.35) NR1H4LMNASLC22A12SLC6A2SLC6A4
SCHEMBL8891457 0.84 NR1H4 (0.35) RAB9ANR1H4KMT2ASLC22A12SLC6A2
SCHEMBL8891512 0.83 HPGD (0.36) HPGDALDH1A1SMN1; SMN2CASP3RAB9A
SCHEMBL8889886 0.83 HPGD (0.36) HPGDALDH1A1SMN1; SMN2CASP3RAB9A
SCHEMBL8891877 0.83 HPGD (0.36) HPGDALDH1A1SMN1; SMN2CASP3RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997028136-A1 BENZOYLISOXAZOLES AND 2-CYANO-1,3-DIONE DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1997-08-07 WO disclosed