Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.61 |
| ▸ | PDE4A | P27815 | 9/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.61 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890987 | 0.89 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8891532 | 0.85 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8891122 | 0.82 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890532 | 0.79 | PDE4D (0.70) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL30614148 | 0.79 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8892506 | 0.78 | PDE4B (0.76) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.78 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8888978 | 0.78 | PDE4D (0.65) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890369 | 0.77 | PDE4B (0.74) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890145 | 0.77 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |