SCHEMBL505269

SCHEMBL505269

O=C(O)c1ccc(-c2cccc(F)c2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.64
BAD Q92934 1/20 0.64
ESR2 Q92731 1/20 0.60
TRIM24 O15164 1/20 0.59
TRIM33 Q9UPN9 1/20 0.59
KDM4E B2RXH2 1/20 0.58
LMNA P02545 1/20 0.58
HSD17B10 Q99714 1/20 0.58
RXRA P19793 4/20 0.57
RXRB P28702 4/20 0.57
RXRG P48443 1/20 0.57
BCL2 P10415 1/20 0.57
TTR P02766 1/20 0.56
DCLRE1B Q9H816 1/20 0.55
TAAR1 Q96RJ0 2/20 0.55
KMO O15229 1/20 0.55
EGFR P00533 1/20 0.55
NR4A2 P43354 2/20 0.51
NR4A1 P22736 1/20 0.51
NR4A3 Q92570 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30189289 1.00 BCL2L1 (0.64) BCL2L1BADESR2TRIM24TRIM33
SCHEMBL121809 0.86 KMO (0.68) ESR2RXRARXRBDCLRE1BKMO
SCHEMBL16166011 0.86 KMO (0.72) BCL2L1BADTRIM24TRIM33RXRA
SCHEMBL30066684 0.86 KMO (0.72) BCL2L1BADTRIM24TRIM33RXRA
SCHEMBL3210250 0.85 KMO (0.60) ESR2RXRARXRBDCLRE1BKMO
SCHEMBL8889438 0.84 PDGFRB (0.55) BCL2L1BADTRIM24TRIM33RXRA
SCHEMBL29906143 0.84 KMO (0.76) BCL2L1BADTRIM24TRIM33RXRA
SCHEMBL2346605 0.84 KMO (0.76) BCL2L1BADTRIM24TRIM33RXRA
SCHEMBL27607318 0.83 TSHR (0.67) BCL2L1BADTRIM24TRIM33RXRA
SCHEMBL11134357 0.83 MAPT (0.62) ESR2LMNADCLRE1BTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090023741-A1 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR BAYER SCHERING PHARMA AG (DE) 2009-01-22 US claimed
US-7109243-B2 Inhibitors of cathepsin S IRM LLC (BM) 2006-09-19 US claimed
US-20240228504-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2024-07-11 US disclosed
US-20240228504-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2024-07-11 US disclosed
US-20240228504-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2024-07-11 US disclosed
EP-4149945-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME Arbutus Biopharma Corporation (CA) 2023-03-22 EP disclosed
US-20220184041-A1 (AZA)Benzothiazolyl Substituted Pyrazole Compounds PFIZER INC. (US) 2022-06-16 US disclosed
WO-2022112919-A1 (AZA)BENZOTHIAZOLYL SUBSTITUTED PYRAZOLE COMPOUNDS PFIZER INC. (US) 2022-06-02 WO disclosed
WO-2021229302-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2021-11-18 WO disclosed
US-20200399282-A1 INHIBITORS OF TRPC6 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2020-12-24 US disclosed
WO-2020128816-A2 PHARMACEUTICAL COMPOSITIONS AND METHODS COMPRISING A COMBINATION OF A BENZOXAZOLE TRANSTHYRETIN STABILIZER AND AN ADDITIONAL THERAPEUTIC AGENT PFIZER INC. (US) 2020-06-25 WO disclosed
US-20070060587-A1 Indane derivates as muscarinic receptor agonists ELI LILLY AND COMPANY (US) 2007-03-15 US disclosed
US-20070043066-A1 Glutamate aggrecanase inhibitors WYETH (US) 2007-02-22 US disclosed
US-7109243-B2 Inhibitors of cathepsin S IRM LLC (BM) 2006-09-19 US disclosed
US-20060178438-A1 Muscarinic agonists ELI LILLY AND COMPANY (IN) 2006-08-10 US disclosed
US-20060154922-A1 Muscarinic agonists ELILILLY AND COMPANY (US) 2006-07-13 US disclosed
WO-2004084842-A2 INHIBITORS OF CATHEPSIN S IRM LLC (BM) 2004-10-07 WO disclosed
US-20040198780-A1 Inhibitors of cathepsin S IRM LLC (BM) 2004-10-07 US disclosed
EP-0357702-A1 FLUORINATED OLIGOPHENYL DERIVATIVES. MERCK PATENT GMBH (DE) 1990-03-14 EP disclosed
WO-1989006678-A1 FLUORINATED OLIGOPHENYL DERIVATIVES MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1989-07-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060154922-A1 Muscarinic agonists CHRM3, CHRM1, CHRM5 BCL2L1 3965/4885BAD 2091/4885ESR2 1007/4885
US-20060178438-A1 Muscarinic agonists CHRM3, CHRM1, CHRM5 BCL2L1 3965/4885BAD 2091/4885ESR2 1007/4885
US-20200399282-A1 INHIBITORS OF TRPC6 TRPC6, TRPC1, TRPC4 BCL2L1 3557/4885BAD 2961/4885ESR2 3919/4885
US-20240228504-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME SLC10A1, NR1H4, SLC10A2 BCL2L1 3426/4885BAD 369/4885ESR2 3141/4885
US-20070060587-A1 Indane derivates as muscarinic receptor agonists CHRM1, CHRM3, CHRM2 BCL2L1 4339/4885BAD 2547/4885ESR2 728/4885
US-20040198780-A1 Inhibitors of cathepsin S CTSS, CTSK, CTSE BCL2L1 783/4885BAD 475/4885ESR2 3633/4885
US-20090023741-A1 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR PTGER2, PTGER1, PTGDR2 BCL2L1 3789/4885BAD 2905/4885ESR2 37/4885
US-20220184041-A1 (AZA)Benzothiazolyl Substituted Pyrazole Compounds TTR, APOB, SERPINB6 BCL2L1 3097/4885BAD 3897/4885ESR2 3824/4885
US-20070043066-A1 Glutamate aggrecanase inhibitors ADAMTS5, ADAMTS1, ADAMTS7 BCL2L1 4519/4885BAD 3116/4885ESR2 2534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.