Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | HNF4A | P41235 | 4/20 | 0.43 |
| ▸ | RARA | P10276 | 2/20 | 0.39 |
| ▸ | RARB | P10826 | 2/20 | 0.39 |
| ▸ | RARG | P13631 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889384 | 1.00 | RXRA (0.47) | RXRAPPARGNR1H3HNF4ARARA | |
| SCHEMBL8889198 | 0.99 | RXRA (0.46) | RXRAPPARGNR1H3HNF4ARARA | |
| SCHEMBL727912 | 0.91 | RXRA (0.46) | RXRAPPARGNR1H3HNF4ARARA | |
| SCHEMBL7156085 | 0.85 | RXRA (0.48) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL7207907 | 0.80 | RXRA (0.47) | RXRAPPARGNR1H3HNF4ARARA | |
| SCHEMBL6917266 | 0.80 | RXRA (0.46) | RXRAPPARGNR1H3HNF4ARARA | |
| SCHEMBL6918206 | 0.79 | RXRA (0.47) | RXRAPPARGNR1H3HNF4ARARA | |
| SCHEMBL6017468 | 0.79 | RXRA (0.43) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL8890044 | 0.78 | RXRA (0.35) | RXRAPPARGHNF4ARARARARB | |
| SCHEMBL8887720 | 0.77 | RXRA (0.47) | RXRAPPARGNR1H3HNF4ARARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012853-A1 | DIMER-SELECTIVE RXR MODULATORS AND METHODS FOR THEIR USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1997-04-10 | — | — | WO | disclosed |