Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889522 | 0.91 | PDGFRB (0.47) | PDGFRBPDGFRAFFAR4FFAR1GRIN2B | |
| Hydrochloric Acid SCHEMBL8501617 | 0.79 | AKR1C3 (0.58) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| Hydrochloric Acid SCHEMBL8888409 | 0.79 | FFAR1 (0.50) | PDGFRBPDGFRAFFAR4FFAR1GRIN2B | |
| SCHEMBL8890269 | 0.77 | FFAR1 (0.48) | PDGFRBPDGFRAFFAR1GRIN2BMAP4K4 | |
| Hydrochloric Acid SCHEMBL8888121 | 0.77 | GRIN2B (0.43) | PDGFRBPDGFRAGRIN2BMAP4K4NTSR1 | |
| SCHEMBL8499905 | 0.76 | PDGFRB (0.52) | PDGFRBPDGFRAFFAR1GRIN2BMAOB | |
| SCHEMBL11806475 | 0.76 | SLC1A1 (0.60) | FFAR1MAOBPPARGPPARAPLA2G10 | |
| SCHEMBL14640308 | 0.76 | SLC1A1 (0.60) | FFAR1MAOBPPARGPPARAPLA2G10 | |
| SCHEMBL8502256 | 0.75 | CSNK2A2 (0.54) | PDGFRBPDGFRAGRIN2BMAP4K4CSNK1G2 | |
| SCHEMBL8887119 | 0.75 | PDGFRB (0.47) | PDGFRBPDGFRAGRIN2BMAP4K4CSNK1G2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |