Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 10/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887112 | 0.82 | PDGFRB (0.45) | PDGFRBPDGFRADPP4PDE3BPDE3A | |
| SCHEMBL8499648 | 0.82 | PDE3B (0.55) | PDGFRBPDGFRALTB4RPDE3BPDE3A | |
| SCHEMBL8499652 | 0.82 | PPARG (0.54) | PDGFRBPDGFRADPP4PPARGPPARA | |
| SCHEMBL8889522 | 0.81 | PDGFRB (0.47) | PDGFRBPDGFRADPP4PPARGPPARA | |
| SCHEMBL8501414 | 0.80 | PDE3B (0.58) | PDGFRBPDGFRALTB4RPDE3BPDE3A | |
| SCHEMBL8502489 | 0.79 | PDGFRB (0.52) | PDGFRBPDGFRAPDE3BPDE3AP2RY12 | |
| SCHEMBL8501205 | 0.78 | PDGFRB (0.51) | PDGFRBPDGFRADPP4DHODHGRIN2B | |
| SCHEMBL8501209 | 0.78 | AKR1C3 (0.60) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| Hydrochloric Acid SCHEMBL8503310 | 0.77 | PDGFRB (0.52) | PDGFRBPDGFRAPDE3BPDE3AP2RY12 | |
| Hydrochloric Acid SCHEMBL8504144 | 0.76 | PDGFRB (0.51) | PDGFRBPDGFRAGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |