Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.65 |
| ▸ | APP | P05067 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | RAD52 | P43351 | 2/20 | 0.62 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.62 |
| ▸ | TOP2A | P11388 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 2/20 | 0.60 |
| ▸ | ACP1 | P24666 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ALPG | P10696 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NCF1 | P14598 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30621755 | 1.00 | TLR9 (0.65) | TLR9APPPOLBRAD52SMARCA2 | |
| SCHEMBL30125367 | 0.92 | POLB (0.70) | TLR9APPPOLBRAD52TOP2A | |
| SCHEMBL8906802 | 0.92 | POLB (0.70) | TLR9APPPOLBRAD52TOP2A | |
| SCHEMBL8907169 | 0.86 | APP (0.62) | TLR9APPPOLBTOP2APDE5A | |
| Hydrochloric Acid SCHEMBL11741441 | 0.85 | APP (0.60) | TLR9APPPOLBTOP2APDE5A | |
| Hydrochloric Acid SCHEMBL8904749 | 0.85 | APP (0.60) | TLR9APPPOLBTOP2APDE5A | |
| SCHEMBL1090319 | 0.84 | TLR9 (0.67) | TLR9APPPOLBRAD52SMARCA2 | |
| SCHEMBL4904310 | 0.83 | APP (0.70) | APPPDE5AACP1FLT3ALDH1A1 | |
| SCHEMBL8907554 | 0.82 | TLR9 (0.65) | TLR9POLBRAD52SMARCA2TOP2A | |
| SCHEMBL14758284 | 0.81 | POLB (0.86) | TLR9POLBRAD52SMARCA2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100395-A1 | QUINAZOLINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER | Trobio Therapeutics Pty Ltd (AU) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021155426-A1 | QUINAZOLINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER | TroBio Therapeutics Pty Ltd (AU) | 2021-08-12 | — | — | WO | disclosed |
| WO-1997020822-A1 | QUINAZOLIN-2,4-DIAZIRINES AS NPY RECEPTOR ANTAGONIST | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |