Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.62 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 8/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.57 |
| ▸ | TOP2A | P11388 | 1/20 | 0.54 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11741441 | 0.99 | APP (0.60) | APPSLC2A1FLT3POLBPDE5A | |
| Hydrochloric Acid SCHEMBL8904749 | 0.99 | APP (0.60) | APPSLC2A1FLT3POLBPDE5A | |
| SCHEMBL8906085 | 0.92 | SLC2A1 (0.71) | APPSLC2A1FLT3POLBPDE5A | |
| Hydrochloric Acid SCHEMBL8891454 | 0.91 | POLB (0.72) | APPSLC2A1FLT3POLBPDE5A | |
| SCHEMBL8890410 | 0.86 | TLR9 (0.65) | APPFLT3POLBPDE5ATOP2A | |
| SCHEMBL30621755 | 0.86 | TLR9 (0.65) | APPFLT3POLBPDE5ATOP2A | |
| SCHEMBL4904310 | 0.84 | APP (0.70) | APPSLC2A1FLT3PDE5A | |
| SCHEMBL1085522 | 0.82 | POLB (0.83) | SLC2A1FLT3POLBPDE5ATLR9 | |
| SCHEMBL15502283 | 0.81 | ACP1 (0.68) | APPSLC2A1POLBPDE5A | |
| SCHEMBL8906802 | 0.81 | POLB (0.70) | APPSLC2A1FLT3POLBPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997020823-A2 | 2-AMINO QUINAZOLINE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |
| US-4048312-A | 2,4-Diaminoquinazolines as antithrombotic agents | ELI LILLY AND COMPANY (US) | 1977-09-13 | — | — | US | disclosed |
| US-3956495-A | 2,4-Diaminoquinazolines as antithrombotic agents | ELI LILLY AND COMPANY (US) | 1976-05-11 | — | — | US | disclosed |